™™| 09/06/10 | |||
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Technology name:
Technology description: Endostatin is a potent anti-angiogenic protein capable of inhibiting the growth of oncogenic tumors. The utility of endostatin is limited due to the fact that the protein has a short half-life thus needs frequent dosing, and invariably results in low concentration at the site of tumors. To increase efficacy, the inventors have combined endostatin with the targeting specificity of an anti-tumor antibody by producing antibody-endostatin fusion proteins specific for the HER2/neu tumor antigen. The invention relates to the development of these tumor-targeting chimeric molecules containing both (1) anti-angiogenic agent and (2) a carrier domain such as all or a portion of an immunoglobulin (Ig) molecule. Furthermore, it provides methods and compositions for targeting a chimeric molecule containing both (1) anti-angiogenic agent and (2) a carrier domain such as all or a portion of an Ig molecule to a tumor. | |||